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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCL1
All Species:
27.27
Human Site:
S590
Identified Species:
46.15
UniProt:
Q15111
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15111
NP_006217.3
1095
122728
S590
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Chimpanzee
Pan troglodytes
XP_001169560
1095
122728
S590
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Rhesus Macaque
Macaca mulatta
XP_001089483
1095
122754
S590
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Dog
Lupus familis
XP_536020
1096
122535
S591
K
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q3USB7
1096
122654
S591
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
H
Rat
Rattus norvegicus
Q62688
1096
122754
S591
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507313
1051
118878
S547
K
D
L
S
E
L
V
S
I
C
K
S
I
Q
F
Chicken
Gallus gallus
Q2VRL0
637
72514
L201
L
L
K
G
C
R
C
L
E
I
D
C
W
D
G
Frog
Xenopus laevis
Q32NH8
758
87399
G322
R
G
Q
S
S
I
E
G
Y
I
R
A
L
K
R
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
R348
S
S
T
E
P
Y
I
R
A
L
N
Q
G
C
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
N555
P
W
L
S
S
M
V
N
Y
A
Q
P
I
K
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_741067
1068
120024
V555
L
V
P
V
F
F
N
V
K
T
L
N
D
L
L
Sea Urchin
Strong. purpuratus
XP_001178766
684
77475
E248
G
E
V
T
D
E
D
E
G
S
D
T
D
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32383
869
100529
N433
I
D
I
W
D
G
E
N
G
P
V
V
C
H
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
98.7
96.4
N.A.
94.3
94.1
N.A.
62.9
21.7
24.7
27.9
N.A.
20
N.A.
39
35.8
Protein Similarity:
100
100
99.2
98.5
N.A.
96.6
96.6
N.A.
77.1
34.8
40.4
42.3
N.A.
40.2
N.A.
59.4
48.1
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
66.6
0
13.3
0
N.A.
20
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
0
46.6
6.6
N.A.
60
N.A.
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
8
0
8
0
0
50
0
8
8
8
0
% C
% Asp:
0
15
0
0
58
0
8
0
0
0
15
0
15
8
0
% D
% Glu:
0
50
0
8
8
8
15
8
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
15
% F
% Gly:
8
8
0
8
0
8
0
8
15
0
0
0
8
0
22
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% H
% Ile:
8
0
8
0
0
8
8
0
50
15
0
0
15
0
0
% I
% Lys:
15
0
8
0
0
0
0
0
8
0
50
0
0
15
0
% K
% Leu:
15
8
58
0
0
50
0
8
0
8
8
0
8
8
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
15
0
0
8
8
0
0
0
% N
% Pro:
8
0
8
0
8
0
0
0
0
8
0
8
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
8
8
0
50
0
% Q
% Arg:
43
0
0
0
0
8
0
8
0
0
8
0
0
8
15
% R
% Ser:
8
8
0
65
15
0
0
50
0
8
0
50
0
0
0
% S
% Thr:
0
0
8
8
0
0
0
0
0
8
0
8
0
0
0
% T
% Val:
0
8
8
8
0
0
58
8
0
0
8
8
43
0
0
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
15
0
0
0
0
0
36
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _